The Versalis/CB&I Isopropanol process produces isopropanol (IPA) by a two step process: hydrogenation of acetone to IPA, followed by distillation of the raw IPA to produce a high purity product. The first step is the hydrogenation of acetone with hydrogen to yield raw IPA. Excess hydrogen is recovered and recycled to the acetone hydrogenation reactor. The hydrogenation reaction operating conditions and hydrogen partial pressure are optimized to give almost complete conversion of acetone with extremely high selectivity to IPA. The raw IPA is then purified in a series of two distillation columns to produce a finished high purity (99.9 wt% dry basis) IPA product and an azeotropic IPA byproduct containing the water entering the process from the feeds. A small amount of heavy ends by-product containing mostly butanol and methyl isobutyl carbinol (MIBC) is also produced in the unit.